Intermediates
| NAME OF DRUG INTERMEDIATE | CAS | END USE |
|---|---|---|
| N-Methyl-4-chloropiperidene | 5570-77-4 | Alcaftadine |
| Dibenzosuberone | 1210-35-1 | Amitriptyline HCl & Nortriptyline HCl |
| 3-(N,N, Di methyl amino) propylchloride HCl | 5407-04-5 | Amitriptyline HCl & Nortriptyline HCl |
| 4-(2-Chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-2-(phthalimidoethoxy)methyl-1,4-dihydropyridine (Phthaloyl Amlodipine) | 88150-62-3 | Amlodipine Besilate / Amlodipine Maleate |
| 2-Methyl-oxirane-2-carboxylic acid (4- cyano-3- trifluoromethylphenyl)-amide | 90357-51-0 | Anastrazole |
| 4-Benzyloxy aniline hydrochloride | 51388-20-6 | Bazedoxifene |
| 4-Benzyloxy-2-bromo propiophenone | 35081-45-9 | Bazedoxifene |
| α-(-4-Chlorophenyl) pyridine -2-methanol | 27652-89-7 | Bepotastine Besilate |
| 2-((4-Chlorophenyl) (4-piperdinnyloxy) methyl pyridine | 122368-54-1 | Bepotastine Besilate |
| 4-Hydroxypiperidine | 5382-16-1 | Bepotastine Besilate |
| 2-2'-[5-(Bromomethyl)benzene-1,3- diyl]bis(2-methylpropanenitrile) | 120511-84-4 | Bicalutamide |
| 2-Bromo-3'-chloro-propiophenone | 34911-51-8 | Bupropion Hydrochloride |
| 2-Cyclohexen-1-one | 930-68-7 | Carprofen |
| 4-(2,3-epoxy, propoxyyl ) carbazole | 51997-51-4 | Carvedilol |
| 1-(Diphenyl methyl) piperazine | 841-77-0 | Cinnarizine |
| Ethyl 4-amino-3-methoxypiperidine-1-carboxylate hydrochloride | 83863-71-2 | Cisapride Monohydrate |
| 4-Amino-5-chloro-2-methoxy-N-(3-methoxy-piperidin-4-yl) benzamide | 221180-26-3 | Cisapride Monohydrate |
| s(+) - 2- Chlorophenylglycine methylester tarterate | 141109-14-0 | Clopidogrel Bi Sulphate |
| Toluene-4-sulfonicacid thiophene-2-yl-ethylester | 40412-06-4 | Clopidogrel Bi Sulphate |
| Methyl (2 – Chlorophenyl ){(2-(2-thienyl) ethyl) amino)acetate hydrochloride | 141109-19-5 | Clopidogrel Bi Sulphate |
| N-Boc-4-hydroxy piperidine | 109384-19-2 | Crizotinib |
| Dibenzosuberenone | 2222-33-5 | Cyclobenzaprine HCl |
| 3-(N,N Di methyl amino) propylchloride HCL | 54077-04-5 | Cyclobenzaprine HCl |
| Dibenzosuberenone | 2222-33-5 | Cyproheptadine HCl |
| N-Methyl-4-chloro piperidine | 5570-77-4 | Cyproheptadine HCl |
| Ethyl - [[3-amino-4-(methylamino) benzoyl]-[pyridin-2-yl-beta-amino] propanoate | 212332-56-0 | Dabigatran Etexilate Mesylate |
| 2-[(4-cyanophenyl)amino]acetic acid | 42288-26-6 | Dabigatran Etexilate Mesylate |
| 3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester | 211915-84-3 | Dabigatran Etexilate Mesylate |
| N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester | 429658-95-7 | Dabigatran Etexilate Mesylate |
| Ethyl 3-(((2-(((4-((((hexyloxy) carbonyl) amino) iminomethyl) phenyl) amino)methyl)-1-methyl-1H-benzimidazol-5-yl)carbonyl)(pyridin-2-yl)amino) propanoate | 211915-06-9 | Dabigatran Etexilate Mesylate |
| (R)-3-Amino-1-Butanol | 61477-40-5 | Dolutegravir |
| 2,4-Difluorobenzylamine | 72235-52-0 | Dolutegravir |
| 5-Benzyloxy-4-hydroxy-6-hydroxymethyl nicotinic acid | 906657-91-8 | Dolutegravir |
| 1-(3-Chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one | 62780-89-6 | Domperidone & Domperidone Maleate |
| 5-Chloro 1,3 dihydro -1- (4-piperidinyl) -2H- benzimidazol - 2 -one | 53786-28-0 | Domperidone & Domperidone Maleate |
| 4-[(5,6-Dimethoxy-1-indanon-2-yl) methyl] piperidine | 120014-30-4 | Donepezil |
| 5,6-dimethoxy-2-(pyridine-4-yl)-methylene-indan-1-one | 4803-74-1 | Donepezil |
| N-Benzylpiperidine-4-carboxaldehyde | 22065-85-6 | Donepezil |
| 5, 6-Dimethoxy-1-indanone | 2107-69-9 | Donepezil |
| (±)-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4- piperidinyl]methyl]-1H-inden-1-one. (Donepezil base) | 120014-06-4 | Donepezil |
| 4-(Diphenyl methoxy)-1-piperidine HCl | 132-18-3 | Ebastine |
| 4-(Diphenyl methoxy) piperidine | 58258-01-8 | Ebastine |
| 4-Tert butyl-4-chlorobutyrophenone | 43076-61-5 | Ebastine |
| 3,4-Dihydroxy-5-nitrobenzaldehyde | 116313-85-0 | Entacapone |
| 4-Hydroxy-3-methoxy-5-nitrobenzaldehyde (5-Nitrovanillin) | 6635-20-7 | Entacapone |
| 2-Butyl-4-formalimidazole | 68282-49-5 | Eprosartan |
| 1-(2-phenylethyl) piperidin-4-one | 39742-60-4 | Fentanyl |
| N-phenyl-1-(2-phenylethyl) piperidin-4-amine | 21409-26-7 | Fentanyl |
| 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid | 83799-24-0 | Fexofenadine HCl |
| Methyl 4-[4-[4-hydroxydiphenylmethyl)-1-piperidinyl]oxobutyl]-2,2-dimethyl benzene acetate | 154477-55-1 | Fexofenadine HCl |
| 2-(4-(cyclopropanecarbonyl)phenyl)-2-methylpropanoic acid | 162096-54-0 | Fexofenadine HCl |
| 1-[bis(4-fluorophenyl)methyl]piperazine | 27469-60-9 | Flunarizine Di hydrochloride |
| 2-Methyl-3-(trifluoromethyl) aniline | 54396-44-0 | Flunixin |
| Diethyl-2 (3-fluoro-4-nitrophenyl)-2-methylmalonate | 78543-06-3 | Flurbiprofen |
| Diethyl-2-(4-amino-3-fluorophenyl)-2- methylmalonate | 78543-08-5 | Flurbiprofen |
| Diethyl 2-[2-fluro-4-biphenyl-4-yl]-2 methylmalonate | 42771-81-3 | Flurbiprofen |
| 1,1(4-Chlorobutylidene) Bis-(4-fluorobenzene) | 3312-04-7 | Flusipirilene |
| 4-Chloro-4'-fluoro-butyrophenone | 3874-54-2 | Haloperidol |
| 4-(4-Chlorophenyl)-4-hydroxy piperidine | 39512-49-7 | Haloperidol |
| 2-[4-(Amino methyl) phenoxy]-N, N-dimethyl ethanamine | 20059-73-8 | Itopride HCl |
| 4-[4-[(4-Hydroxyphenyl)- 1-piperazinyl]phenyl]- 2,4-dihydro-2-(1-methyl propyl)-3H-1,2,4-triazole-3-one | 89848-21-5 | Itraconazole |
| Cis-2-(2,4-Dichloro Phenyl)-2 (1H-1,2,4 Triazole-l-yl methyl)-1,3-Dioxolane-4yl methyl Methane Sulphonate | 67914-86-7 | Itraconazole |
| Cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate (Cis Tosylate) | 134071-44-6 | Ketoconazole |
| 1-Acetyl-4-(4-hydroxyphenyl)-piperazine | 67914-60-4 | Ketoconazole |
| Phenyl(1H-pyrrol-2-yl)methanone | 7697-46-3 | Ketorolac tromethamine |
| Triethyl[5-benzyl-1H pyrrol- yl]methane tri carboxylate | 136116-84-2 | Ketorolac tromethamine |
| 5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid | 74103-06-3 | Ketorolac tromethamine |
| N-Methyl-4-chloro-piperidine | 5570-77-4 | Ketotifene |
| 2-chloromethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride | 127337-60-4 | Lansoprazole |
| 2-[[(3-Methyl-4-(2,2,2-trifluoroethoxy)- 2-pyridinyl) methyl]thio] -1H-benzimidazole | 103577-40-8 | Lansoprazole |
| (R)-3-(Boc-Amino)Piperidine | 309956-78-3 | Linagliptin |
| (R)-3-Piperidinamine dihydrochloride | 334618-23-4 | Linagliptin |
| 4-(4-Chlorophenyl)-4-hydroxy piperidine | 39512-49-7 | Loperamide HCl |
| N,N-Dimethyl(tera hydro-3,3-diphenyl)-2-furyliden ammonium bromide (Furanuminium Bromide ) | 37743-18-3 | Loperamide HCl |
| 1,1-Diphenyl-3-butyrolactone | 956-89-8 | Loperamide HCl |
| 4-Bromo-2-2-diphenylbutyric acid | 37742-98-6 | Loperamide HCl |
| 3(2-(3-Chloro phenyl)ethyl) cyano pyridine | 31255-55-7 | Loratadine & Desloratadine |
| 8-Chloro-5,6 dihydro(11H)-benzo[5,6] cyclohepta (1,2b) pyridine -11-one | 31251-41-9 | Loratadine & Desloratadine |
| 8 Chloro-11-[(N-methyl)-4-piperidylidene]-6, 11-dihydro-5H-benzo [5,6]cyclohepta (1,2b) Pyridine (Methyl Loratadine) | 38092-89-6 | Loratadine & Desloratadine |
| {3-[2-(3-Chlorophenyl)ethyl]pyridine-2-yl}-(1-methyl piperidine-4-yl) | 119770-60-4 | Loratadine & Desloratadine |
| N-Methyl-4-chloro piperidine | 5570-77-4 | Loratadine & Desloratadine |
| 2n-Butyl-4-chloro-[1-(2'-cyanobiphenyl-4-yl) methyl]-5-(hydroxymethyl)-imidazole | 114772-55-3 | Losartan Potassium |
| 5-(4'-Bromomethyl-1, 1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole (TTBB) | 124750-51-2 | Losartan Potassium |
| 2-Butyl-4-chloro-1-[2'(2-trityl-2H-tetrazol-5-yl) biphenyl-4-ylmethyl]-1H- imidazol- 5-yl (Trityl losartan ). | 133909-99-6 | Losartan Potassium |
| 2-N-Butyl-4-chloro-1-[(2"-H tetrazol-5-yl)(1,1"- Biphenyl)-4yl)Methyl]-1H imidazole-5-methanol(Losartan Base) | 11479-26-4 | Losartan Potassium |
| Alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol | 24155-42-8 | Miconazole / Voriconazole / Tioconazole |
| 1-(Mercaptomethyl)-cyclopropane acetic acid | 162515-68-6 | Montelukast Sodium |
| Methyl 1-(mercaptomethyl) cyclopropaneacetate | 152922-73-1 | Montelukast Sodium |
| 2-(2-(3-(2-(7- chloro-2-quinolinyl)-ethenylphenyl)-3-hydroxypropyl) phenyl)-2-propanol | 142569-70-8 | Montelukast Sodium |
| 6-Fluoro-3,4-dihydro-2H-chromene – 2-carboxylicacid | 99199-60-7 | Nebivolol |
| (2S)-6-Fluoro-2-[(2S)-oxiran-2-yl)-3,4-dihydro-2H – chromene (Isomer - A ) | 129101-36-6 | Nebivolol |
| (2R)-6-Fluoro-2-[(2R)-oxiran-2-yl)-3,4-dihydro-2H – chromene (Isomer - B ) | 129101-37-7 | Nebivolol |
| 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-[(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid ethyl ester) | 144690-33-5 | Olmesartan |
| 5-Methoxy – 2-oxo-1,3-dioxol - 4 - yl ) methyl - 4 - (1-hydroxy -1 - methylethyl -2 propyl-1- (2 –(2-triphenylmethyl ) -2H – tetrazole -5 – yl ) biphenyl -4-yl ) methyl ) -1H-imidazole – 5 – carboxylate | 144690-92-6 | Olmesartan |
| Ethyl 4 - (1-hydroxy -1 - methylethyl ) -2-propyl-imidazole-5-carboxylate ( OLM 20 ) | 144689-93-9 | Olmesartan |
| 4-( Cyclomethyl carbonyl ) -5 - methyl – 1,3-dioxol-2-one ( OLM 45 ) | 80841-78-7 | Olmesartan |
| 3-((Dimethylamino) methyl)-2, 3-dihydro-9-methyl-1H-carbazol-4(9H)-one hydrochloride | 153139-56-1 | Ondansetron hydrochloride |
| 1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one (Ondansetron free base) | 99614-02-5 | Ondansetron hydrochloride |
| 1-(3-chloropropyl)-1,3-dihydro-2H-benzimidazol-2- | 62780-89-6 | Oxatomide |
| 1-(Diphenylmethyl) piperazineone | 841-77-0 | Oxatomide |
| 3,4 Dimethoxy-2-chloromethyl pyridine Hydrochloride | 72830-09-2 | Pantoprazole Sodium |
| 5-(Difluoromethoxy)-2-mercapto-1H- benzimidazole | 97963-62-7 | Pantoprazole Sodium |
| 5-(Difluoromethoxy)-2- {[( 3,4 Dimethoxypyridin - 2- yl) methyl] thio}-1H-benzimidazolee | 102625-64-9 | Pantoprazole Sodium |
| 4-(2-Keto-1-benzimidozolinyl) piperidine | 20662-53-7 | Pimozide |
| 1-Chloro-4,4-di (4-fluorophenyl)butane | 3312-04-7 | Pimozide |
| 2-Bromo-4,5-dimethoxybenzyl bromide | 53207-00-4 | Pinaverium Bromide |
| (+)-3-(carbamoy methyl)-5-methyl hexanoic acid | 181289-15-6 | Pregabalin |
| (R)-(-)-3-carbamoy methyl)-5-methyl hexanoic acid | 181289-33-8 | Pregabalin |
| 1-(3-Methoxy propyl) piperidine-4-one | 16771-85-0 | Prucalopride |
| Phenyl-2-(phenylthio)-phenyl carbamate | 111974-73-3 | Quetiapine fumarate |
| Dibenzo[b,f][1,4]thiazepine-11-(10H)one | 3159-07-7 | Quetiapine fumarate |
| 11-Piperazinyl-dibenzo[b,f][1,4]thiazepine Hydrochloride Salt | 5747-48-8 | Quetiapine fumarate |
| 11-Piperazin-1-yldibenzo[b,f][1,4] thiazepine dihydrochloride | 111974-74-4 | Quetiapine Hemifumarate |
| 2-Bromo-4-hydroxyacetophenone | 2491-38-5 | Ractopamine |
| 1-Isobutyl-4-piperidone | 72544-16-2 | Rifabutin |
| 4- Hydroxypiperidine | 5382-16-1 | Rupatadine |
| 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)-4-piperidinylidene]- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine tri hydrochloride (Rupatadine tri hydrochloride ) | 156611-76-6 | Rupatadine Fumarate |
| 3,4-(Methylenedioxy)-6-methyl benzylchloride | 117661-72-0 | Sitaxsentan |
| (1R,3R)-methyl-1,2,3,4-tetrahydro-2-chloroacetyl-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate | 171489-59-1 | Tadalafil |
| [1,1'-Biphenyl]-2-carbonitrile,4'-[(1,4'-dimethyl -2'-propyl [2,6”-bi-1H-benzimidazole ] -1'-yl) methyl ] – (1,1-biphenyl)-2-carbonitrile | 144702-27-2 | TelmIsartan |
| 2,3,4,5-Di-o-isopropylidene-beta-D-fructopyranose (Topiacetal) | 20880-92-6 | Topiramate |
| 1-(Pyridine-2-yl)-3-(pyrrolidin-1-yl)-1-p-tolylpropan-1-ol | 70708-28-0 | Triprolidine hydrochloride |
| 2-[(1E)-1-(4-Methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]pyridine (Triprolidine base) | 486-12-4 | Triprolidine hydrochloride |
| 2-[(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl) methoxy]ethyl N-[(benzyloxy)carbonyl]-L-valinate. | 124832-31-1 | Valacyclovir |
| N-Triphenylmethyl-5-[(4-bromomethyl) biphenyl-2-yl]tetrazole | 124750-51-2 | Valsartan |
| 4,5-Dihydro-6-oxime-imidazo [4,5,1-jk] [1] benzazepine-2,6,7 (1H)-trione | 92260-82-7 | Zilpaterol |
| 5,6-Dihydroimidazo[4,5,1-jk] [1] benzazepine-2,7(1H,4H)-dione | 92260-81-6 | Zilpaterol |
| 6-Chloro-5-(2-chloroethyl)-1,3-dihydro-indole-2-one | 118289-55-7 | Ziprasidone |